Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

Published:2016-01-25 Issue:4 Volume:138 Page:1430-1445
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Kern Jeffrey C.,Cancilla Mark,Dooney Deborah,Kwasnjuk Kristen,Zhang Rena,Beaumont Maribel¹,Figueroa Isabel¹,Hsieh SuChun¹,Liang Linda¹,Tomazela Daniela¹,Zhang Jeffrey¹,Brandish Philip E.,Palmieri Anthony,Stivers Peter,Cheng Mangeng,Feng Guo,Geda Prasanthi,Shah Sanjiv,Beck Andrew²,Bresson Damien²,Firdos Juhi²,Gately Dennis²,Knudsen Nick²,Manibusan Anthony²,Schultz Peter G.²,Sun Ying²,Garbaccio Robert M.

Affiliation:

1. Biologics, Merck & Co., Inc., Palo Alto, California 94304, United States

2. Ambrx, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.5b12547

Reference27 articles.

1. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

2. The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates