Quaternary ammonium substituted pullulan accelerates wound healing and disinfects Staphylococcus aureus infected wounds in mouse through an atypical ‘non-pore forming’ pathway of bacterial membrane disruption

Author:

Roy Shounak1ORCID,Kumari Monika2,Haloi Prakash3,Chawla Saurabh3,Konkimalla V. Badireenath3ORCID,Kumar Ajith1,Kashyap Hemant K.2ORCID,Jaiswal Amit1ORCID

Affiliation:

1. School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Mandi, Himachal Pradesh 175005, India

2. Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India

3. School of Biological Sciences, National Institute of Science Education and Research, HBNI, Jatni, Odisha 752050, India

Abstract

Anionic lipid clustering and membrane depolarization mediated bactericidal action of quaternized pullulan towards wound disinfection and healing.

Funder

Department of Science and Technology, Ministry of Science and Technology, India

University Grants Commission

National Institute of Science Education and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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