Coupling of α-bromoamides and unactivated alkenes to form γ-lactams through EDA and photocatalysis-Reference-Cited by-同舟云学术

Coupling of α-bromoamides and unactivated alkenes to form γ-lactams through EDA and photocatalysis

Published:2023 Issue:6 Volume:14 Page:1569-1574
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Treacy Sean M.¹,Vaz Daniel R.¹^ORCID,Noman Syed²,Tard Cédric²^ORCID,Rovis Tomislav¹^ORCID

Affiliation:

1. Department of Chemistry, Columbia University, New York, NY, 10027, USA

2. Laboratoire de Chimie Moléculaire (LCM), CNRS, École Polytechnique, Institut Polytechnique de Paris, 91120 Palaiseau, France

Abstract

γ-Lactams are privileged heterocycles on route to the synthesis of pharmaceuticals. Herein, we demonstrate the facile synthesis of variously substituted γ-lactams utilizing electron donor–acceptor (EDA) complexes of amines and α-Br-amides.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC05973H

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