Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice-Reference-Cited by-同舟云学术

Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice

Published:2020 Issue:12 Volume:11 Page:10852-10863
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Gu Mingbao¹²³⁴⁵,Jin Jie¹²³⁴⁵,Ren Chenghao¹²³⁴⁵,Chen Ximiao⁶⁴⁵¹⁷,Gao Weiyang¹²³⁴⁵^ORCID,Wang Xiangyang¹²³⁴⁵^ORCID,Wu Yaosen¹²³⁴⁵,Tian Naifeng¹²³⁴⁵,Pan Zongyou¹⁸⁹⁵,Wu Aimin¹²³⁴⁵^ORCID,Zhou Yifei¹²³⁴⁵,Zhang Xiaolei¹²³⁴⁵^ORCID

Affiliation:

1. Department of Orthopaedics

2. The Second Affiliated Hospital

3. and Yuying Children's Hospital of Wenzhou Medical University

4. Wenzhou 325000

5. China

6. Zhejiang Provincial Key Laboratory of Orthopedics

7. Affiliated Hospital of Guilin Medical College

8. The Second Affiliated Hospital of Zhejiang University School of Medicine

9. Hangzhou 310003

Abstract

Akebia Saponin D promotes the translocation of NRF2 into nucleus, activates NRF2/HO-1 pathway and inhibits NF-κB pathway in chondrocytes, and ultimately alleviates osteoarthritis development.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Wenzhou Municipal Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/FO/D0FO01909G

Reference49 articles.

1. Osteoarthritis year in review 2016: clinical