In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis
Author:
Funder
NIH NIAMS F32
GlaxoSmithKline
Trueman Family Endowment
Publisher
Elsevier BV
Subject
Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology
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5. Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes;Tamura;Osteoarthritis Cartilage,2001
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