Charge shielding effects of PEG bound to NH<sub>2</sub>-terminated PAMAM dendrimers – an experimental approach-Reference-Cited by-同舟云学术

Charge shielding effects of PEG bound to NH₂-terminated PAMAM dendrimers – an experimental approach

Published:2023 Issue:16 Volume:19 Page:3033-3046
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Johnston Brandon M.¹²,Grodzinsky Alan J.³⁴⁵,Hammond Paula T.¹²^ORCID

Affiliation:

1. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139, USA

2. Koch Institute for Integrative Cancer Research, 500 Main St, Cambridge, MA, 02139, USA

3. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139, USA

4. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139, USA

5. Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139, USA

Abstract

An experimental technique to probe intramolecular interactions of PEG–PAMAM conjugates and surface charge presentation. Increasing PEG chain length increases non-covalent shielding, but increasing chain density decreases PEG surface association.

Funder

Congressionally Directed Medical Research Programs

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SM/D2SM01698B

Reference51 articles.

1. Structure of PAMAM Dendrimers: Generations 1 through 11

2. Effect of Solvent and pH on the Structure of PAMAM Dendrimers

3. Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

4. PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery

5. Poly(ethylene glycol)-Conjugated PAMAM Dendrimer for Biocompatible, High-Efficiency DNA Delivery

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