Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis-Reference-Cited by-同舟云学术

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

Published:2018-11-28 Issue:469 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Geiger Brett C.¹²^ORCID,Wang Sheryl¹²^ORCID,Padera Robert F.³^ORCID,Grodzinsky Alan J.¹⁴⁵,Hammond Paula T.²⁶^ORCID

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

2. Koch Institute for Integrative Cancer Research, 500 Main Street, Cambridge, MA 02142, USA.

3. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 45 Francis Street, Boston, MA 02115, USA.

4. Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

5. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

6. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Abstract

A charged molecular carrier enables sustained growth factor delivery to cartilage, demonstrating therapeutic benefit in a rat model of osteoarthritis.

Funder

U.S. Department of Defense

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference56 articles.

1. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II

2. The Impact of Osteoarthritis

3. Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

4. Intra-articular Hyaluronic Acid in Treatment of Knee Osteoarthritis

5. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis

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