Star-shaped poly(<scp>l</scp>-lysine) with polyester bis-MPA dendritic core as potential degradable nano vectors for gene delivery-Reference-Cited by-同舟云学术

Star-shaped poly(l-lysine) with polyester bis-MPA dendritic core as potential degradable nano vectors for gene delivery

Published:2023 Issue:27 Volume:14 Page:3151-3159
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Stefanovic Smiljana¹^ORCID,McCormick Katie²³^ORCID,Fattah Sarinj²^ORCID,Brannigan Ruiari⁴,Cryan Sally-Ann²³⁵^ORCID,Heise Andreas¹³⁵^ORCID

Affiliation:

1. Department of Chemistry, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland

2. School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland

3. AMBER, The SFI Advanced Materials and Bioengineering Research Centre, RCSI, Dublin 2, Ireland

4. School of Chemical Sciences, Dublin City University, Collins Avenue, Whitehall, Dublin 9, Ireland

5. Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CURAM), RCSI, Dublin 2, Ireland

Abstract

Efficient initiation from ammonium trifluoroacetate salts (TFA) dendritic end-groups yields well-defined poly(l-lysine) star polypeptides with 8, 16 and 32 arms. Hydrolytic core degradation and plasmid DNA complexation is demonstrated.

Funder

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/PY/D3PY00346A

Reference52 articles.

1. The Promise and the Hope of Gene Therapy

2. The once and future gene therapy

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