Proline isomerization effects in the amyloidogenic protein β2-microglobulin-Reference-Cited by-同舟云学术

Proline isomerization effects in the amyloidogenic protein β2-microglobulin

Published:2021 Issue:1 Volume:23 Page:356-367
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Maschio Maria Celeste¹²³⁴⁵^ORCID,Fregoni Jacopo¹²³⁶⁷,Molteni Carla⁴⁸⁹¹⁰¹¹^ORCID,Corni Stefano¹²³⁶⁷

Affiliation:

1. CNR-Nano S3

2. Modena

3. Italy

4. Department of Physics

5. University of Modena and Reggio Emilia

6. Department of Chemical Sciences

7. University of Padova

8. King's College London

9. Strand

10. London WC2R 2LS

11. UK

Abstract

The protein β₂-microglobulin can aggregate in insoluble amyloid fibrils. By relying on extensive sampling simulations, we study the Pro32 isomerization as a possible triggering factor leading to structural modifications in β₂-m.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D0CP04780E

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