Azide–acetonitrile “click” reaction triggered by Cs2CO3: the atom-economic, high-yielding synthesis of 5-amino-1,2,3-triazoles-Reference-Cited by-同舟云学术

Azide–acetonitrile “click” reaction triggered by Cs2CO3: the atom-economic, high-yielding synthesis of 5-amino-1,2,3-triazoles

Published:2015 Issue:76 Volume:5 Page:62062-62066
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Krishna Patoju M.¹²³⁴⁵,Ramachary Dhevalapally B.¹²³⁴⁵,Peesapati Sruthi¹²³⁴⁵

Affiliation:

1. Catalysis Laboratory

2. School of Chemistry

3. University of Hyderabad

4. Hyderabad-500 046

5. India

Abstract

Medicinally important 5-amino-1,2,3-triazoles were synthesized using a novel Cs₂CO₃-catalyzed azide–acetonitrile [3 + 2]-cycloaddition. Aryl azides and aryl acetonitriles were employed in this transformation resulting in excellent yields with high regioselectivity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA12308A

Reference69 articles.

1. 4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo

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3. Protein Prosthesis: 1,5-Disubstituted[1,2,3]triazoles as cis-Peptide Bond Surrogates

4. Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist

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