Molecular characterization of COVID-19 therapeutics: luteolin as an allosteric modulator of the spike protein of SARS-CoV-2-Reference-Cited by-同舟云学术

Molecular characterization of COVID-19 therapeutics: luteolin as an allosteric modulator of the spike protein of SARS-CoV-2

Published:2022 Issue:1 Volume:7 Page:58-66
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Alvarado Walter¹^ORCID,Perez-Lemus Gustavo R.²,Menéndez Cintia A.²,Byléhn Fabian²^ORCID,de Pablo Juan J.²^ORCID

Affiliation:

1. Biophysical Sciences, University of Chicago, 929 E. 57th Street, Chicago, IL 60637, USA

2. Pritzker School of Molecular Engineering, University of Chicago, 5640 S. Ellis Avenue, Chicago, IL 60637, USA

Abstract

The interactions between the receptor binding domain (RBD) of SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) are crucial for viral entry and subsequent replication.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/ME/D1ME00119A

Reference28 articles.

1. An interactive web-based dashboard to track COVID-19 in real time

2. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

3. A pneumonia outbreak associated with a new coronavirus of probable bat origin

4. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

5. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

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