N,2,6-Trisubstituted 1H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico studies-Reference-Cited by-同舟云学术

N,2,6-Trisubstituted 1H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico studies

Published:2023 Issue:1 Volume:13 Page:399-420
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Pham Em Canh¹^ORCID,Le Thi Tuong Vi²³,Ly Hong Huong Ha⁴,Vo Thi Bich Ngoc⁴,Vong Long B.⁵⁶,Vu Thao Thanh⁷,Vo Duy Duc⁸,Tran Nguyen Ngoc Vi³,Bao Le Khanh Nguyen³,Truong Tuyen Ngoc³^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Hong Bang International University, 700000 Ho Chi Minh City, Vietnam

2. Department of Pharmacology – Clinical Pharmacy, Faculty of Pharmacy, City Children's Hospital, 700000 Ho Chi Minh City, Vietnam

3. Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 700000 Ho Chi Minh City, Vietnam

4. Department of Pharmacognosy & Botany, Faculty of Pharmacy, Hong Bang International University, 700000 Ho Chi Minh City, Vietnam

5. School of Biomedical Engineering, International University, 700000 Ho Chi Minh City, Vietnam

6. Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh 700000, Vietnam

7. Department of Microbiology – Parasitology, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 700000 Ho Chi Minh City, Vietnam

8. Uppsala University, Sweden, Tra Vinh University, Vietnam

Abstract

The purpose of this study is to synthesize novel N,2,6-trisubstituted 1H-benzimidazole derivatives and evaluation of their antibacterial, antifungal, and anticancer activities as well as to study their mechanism of action.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D2RA06667J

Reference52 articles.

1. Microwave assisted synthesis and cytotoxic activity evaluations of new benzimidazole derivatives

2. Synthesis of a Series of Novel 2-Amino-5-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Antibacterial Agents

3. Perspectives of Benzimidazole Derivatives as Anticancer Agents in the New Era

4. Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1H-benzimidazole derivatives as antimicrobial and anticancer agents

5. Synthesis and insight into the structure–activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents

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