Design, synthesis, bio-evaluation, and <i>in silico</i> studies of some N-substituted 6-(chloro/nitro)-1<i>H</i>-benzimidazole derivatives as antimicrobial and anticancer agents-Reference-Cited by-同舟云学术

Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1H-benzimidazole derivatives as antimicrobial and anticancer agents

Published:2022 Issue:33 Volume:12 Page:21621-21646
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Pham Em Canh¹^ORCID,Thi Le Tuong Vi²,Truong Tuyen Ngoc³^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Hong Bang International University, 700000 Ho Chi Minh City, Vietnam

2. Department of Pharmacology – Clinical Pharmacy, Faculty of Pharmacy, City Children's Hospital, 700000 Ho Chi Minh City, Vietnam

3. Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 700000 Ho Chi Minh City, Vietnam

Abstract

The purpose of this study is to synthesize novel N-substituted 6-(chloro/nitro)-1H-benzimidazole derivatives with various substituted aryl groups at position 2 and alkylation at position 1, and evaluate their antimicrobial and anticancer activities.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03491C

Reference45 articles.

1. Synthesis and anticancer activity of some novel 2-substituted benzimidazole derivatives

2. Microwave assisted synthesis and cytotoxic activity evaluations of new benzimidazole derivatives

3. Synthesis and insight into the structure–activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents

4. Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA

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