Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors
Author:
Affiliation:
1. Department of Medicinal Chemistry
2. and the Institute of Structural Biology & Drug Discovery
3. Virginia Commonwealth University
4. Richmond
5. USA
Abstract
A novel clicked bisubstrate analogue (NAM-TZ-SPKRIA) was designed and synthesized to be a potent, selective, and first NTMT1 inhibitor.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00120J
Reference30 articles.
1. Targeting epigenetic enzymes for drug discovery
2. PRMT6 mediates CSE induced inflammation and apoptosis
3. Epigenetic modifications as therapeutic targets
4. α-N-Methylation of Damaged DNA-binding Protein 2 (DDB2) and Its Function in Nucleotide Excision Repair
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