GlyConnect-Ugi: site-selective, multi-component glycoprotein conjugations through GlycoDelete expressed glycans-Reference-Cited by-同舟云学术

GlyConnect-Ugi: site-selective, multi-component glycoprotein conjugations through GlycoDelete expressed glycans

Published:2022 Issue:2 Volume:20 Page:464-471
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Thooft Karel¹²³,Van Breedam Wander²³,Santens Francis²³^ORCID,Wyseure Elise²³,Vanmarcke Sandrine²³,Devos Simon²³,Callewaert Nico²³^ORCID,Madder Annemieke¹^ORCID

Affiliation:

1. Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University, Belgium

2. Medical Biotechnology Centre, VIB, Ghent, Belgium

3. Center for Medical Biotechnology, VIB, Department of Biochemistry and Microbiology, UGent, Technologiepark 75, B-9052 Zwijnaarde-Gent

Abstract

GlycoDelete proteins can be conveniently and site-selectively labeled upon oxidation of their unique glycan structure and their subsequent participation as aldehyde partner in a versatile multicomponent Ugi reaction.

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02299G

Reference60 articles.

1. Glycans of Antibodies as a Specific Site for Drug Conjugation Using Glycosyltransferases

2. Bioconjugation – using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers

3. Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

4. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

5. A “Tag-and-Modify” Approach to Site-Selective Protein Modification

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