The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE
Author:
Affiliation:
1. Department of Chemistry and Molecular Physics
2. Institute of Chemistry of Sao Carlos
3. Sao Paulo University
4. São Carlos-SP
5. Brazil
6. Department of Biochemistry
7. Institute of Chemistry
8. Butantã – São Paulo – SP
Abstract
CDK9 is a prominent member of the transcriptional CDKs subfamily, a group of kinases whose function is to control the primary steps of mRNA synthesis and processing by eukaryotic RNA polymerase II.
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2017/MB/C6MB00387G
Reference165 articles.
1. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.
2. Cyclin-dependent kinases: a family portrait
3. Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation
4. Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase
5. Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro
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