Druggability assessment of mammalian Per–Arnt–Sim [PAS] domains using computational approaches-Reference-Cited by-同舟云学术

Druggability assessment of mammalian Per–Arnt–Sim [PAS] domains using computational approaches

Published:2019 Issue:7 Volume:10 Page:1126-1137
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

de Souza João V.¹²³⁴,Reznikov Sylvia¹²³⁴^ORCID,Zhu Ruidi¹²³⁴,Bronowska Agnieszka K.¹²³⁴^ORCID

Affiliation:

1. School of Natural and Environmental Sciences

2. Newcastle University

3. NE1 7RU Newcastle

4. UK

Abstract

Protein dynamics finely tune the “druggability” of mammalian PAS-B domains, as assessed by atomistic molecular dynamics simulations and hotspot mapping.

Funder

Newcastle University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00148D

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4. Vertebrate-like CRYPTOCHROME 2 from monarch regulates circadian transcription via independent repression of CLOCK and BMAL1 activity

5. Studies on Steroid Receptor Coactivators in Prostate Cancer

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