Discovery and optimisation of pyrazolo[1,5-<i>a</i>]pyrimidines as aryl hydrocarbon receptor antagonists-Reference-Cited by-同舟云学术

Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Bobrovs Raitis¹^ORCID,Terentjeva Svetlana¹,Olafsen Ninni Elise²^ORCID,Dambrauskas Zilvinas³,Gulbinas Antanas³,Maimets Toivo⁴^ORCID,Teino Indrek⁴,Jirgensons Aigars¹^ORCID,Matthews Jason²⁵,Jaudzems Kristaps¹^ORCID

Affiliation:

1. Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV1006, Latvia

2. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway

3. Surgical Gastroenterology Laboratory, Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu 4, 50103 Kaunas, Lithuania

4. Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia

5. Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada

Abstract

The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.

Funder

EEA Grants/Norway Grants

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00266K

Reference26 articles.

1. The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

2. Cryo-EM structure of the cytosolic AhR complex

3. Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor

4. Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex

5. Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation