Improving the solubility and bioavailability of anti-hepatitis B drug PEC via PEC–fumaric acid cocrystal
Author:
Affiliation:
1. Sichuan Kelun Pharmaceutical Research Institute Co., Ltd.
2. Chengdu 610000
3. China
4. College of Chemistry and Chemical Engineering
5. Guangxi University for Nationalities
6. Nanning
Abstract
A cocrystal of PEC with fumaric acid (FUA) (PEC–FUA, 1 : 1) was successfully obtained and characterized. The mean AUC0–24 h of the cocrystal is about 4.2 times that of free PEC.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA06608G
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