Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper-Reference-Cited by-同舟云学术

Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper

Published:2016 Issue:8 Volume:7 Page:5398-5406
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lee Shin Jung C.¹²³⁴¹,Choi Tae Su¹⁵⁶⁴¹,Lee Jong Wha¹⁵⁶⁴¹,Lee Hyuck Jin¹²³⁴,Mun Dong-Gi¹⁷⁸⁹⁴,Akashi Satoko¹⁰¹¹¹²¹³,Lee Sang-Won¹⁷⁸⁹⁴,Lim Mi Hee¹²³⁴,Kim Hugh I.¹⁷⁸⁹⁴

Affiliation:

1. Department of Chemistry

2. Ulsan National Institute of Science and Technology (UNIST)

3. Ulsan 44919

4. Republic of Korea

5. Pohang University of Science and Technology (POSTECH)

6. Pohang 37673

7. Research Institute for Natural Sciences

8. Korea University

9. Seoul 02841

10. Graduate School of Medical Life Science

11. Yokohama City University

12. Yokohama

13. Japan

Abstract

The molecular interaction of hIAPP with Cu(ii) mediates the formation of off-pathway and toxic oligomers which have small-sized and random coil structures.

Funder

National Research Foundation of Korea

Ministry of Education

Korea Health Industry Development Institute

Ministry of Science, ICT and Future Planning

Ministry of Education, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00153J