A highly efficient designer cell for enantioselective reduction of ketones

Author:

Srivastava Gautam1234,Pal Mohan1234,Kaur Suneet1234,Jolly Ravinder S.1234

Affiliation:

1. Department of Chemistry

2. CSIR-Institute of Microbial Technology

3. Chandigarh 160 036

4. India

Abstract

A highly efficient designer cell, surf-crs-gdh, which coexpresses carbonyl reductase (crs) and glucose dehydrogenase (gdh) on the cell surface, has been constructed and its enzyme activities were compared with those of the corresponding cell, cyto-crs-gdh, which coexpresses crs and gdh in cytoplasm.

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Reference29 articles.

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2. K. Götz , L.Hilterhaus and A.Liese, in Enzyme Catalysis in Organic Synthesis, Wiley-VCH Verlag GmbH & Co. KGaA, 2012, pp. 1205–1223

3. K. Nakamura and T.Matsuda, in Enzyme Catalysis in Organic Synthesis, Wiley-VCH Verlag GmbH, 2008, pp. 991–1047

4. Bioreduction of methyl heteroaryl and aryl heteroaryl ketones in high enantiomeric excess with newly isolated fungal strains

5. Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones

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