Succinct synthesis of saturated hydroxy fatty acids andin vitroevaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84-Reference-Cited by-同舟云学术

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Succinct synthesis of saturated hydroxy fatty acids andin vitroevaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84

Published:2017 Issue:6 Volume:8 Page:1360-1365
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Kaspersen Mads Holmgaard¹²³⁴,Jenkins Laura⁵⁶⁷⁸⁹,Dunlop Julia⁵⁶⁷⁸⁹,Milligan Graeme⁵⁶⁷⁸⁹,Ulven Trond¹²³⁴^ORCID

Affiliation:

1. Department of Physics, Chemistry and Pharmacy

2. University of Southern Denmark

3. Odense

4. Denmark

5. Centre for Translational Pharmacology

6. Institute of Molecular, Cell and Systems Biology

7. College of Medical

8. Veterinary and Life Sciences

9. University of Glasgow

Abstract

A concise synthetic protocol enables rapid receptor screening of hydroxy fatty acid.

Funder

Strategiske Forskningsrad

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00130D

Reference30 articles.

1. Complex Pharmacology of Free Fatty Acid Receptors

2. Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry

3. Synthesis of 5-(S)-HETE, 5-(S)-HEPE and (+)-zooxanthellactone: Three hydroxylated polyunsaturated fatty acid metabolites

4. Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins

5. Pro-resolving lipid mediators are leads for resolution physiology

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