Transition metal-free regioselective direct acylation of quinazolines for the synthesis of acylquinazoline derivatives-Reference-Cited by-同舟云学术

Transition metal-free regioselective direct acylation of quinazolines for the synthesis of acylquinazoline derivatives

Published:2023 Issue:42 Volume:21 Page:8603-8616
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chen Wei¹,Fang Jingjun¹,Huang Jian¹,Yang Qin¹,Song Zhibin¹^ORCID,Ding Qiuping¹^ORCID,Wang Hongming²^ORCID,Peng Yiyuan¹^ORCID

Affiliation:

1. Key Laboratory for Green Chemistry of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022, China

2. Institute for Advanced Study, Nanchang University, Nanchang 330031, China

Abstract

An efficient method for direct regioselective acylation of quinazolines under metal-free conditions was developed. The acylation reaction of quinazolines gave corresponding acyl quinazolines in ethyl acetate with good to excellent yields and excellent functional group tolerance and site selectivity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01349A

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