Isoquinoline derivatives as potent CRTH2 antagonists: Design, synthesis and SAR-Reference-Cited by-同舟云学术

Isoquinoline derivatives as potent CRTH2 antagonists: Design, synthesis and SAR

Published:2013-12 Issue:24 Volume:21 Page:7674-7685
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Nishikawa-Shimono Rie,Sekiguchi Yoshinori,Koami Takeshi,Kawamura Madoka,Wakasugi Daisuke,Watanabe Kazuhito,Wakahara Shunichi,Kimura Kayo,Yamanobe Susumu,Takayama Tetsuo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

2. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases

3. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

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