Cu(i) catalysis for selective condensation/bicycloaromatization of two different arylalkynes: direct and general construction of functionalized C–N axial biaryl compounds

Author:

Shang Qian1,Tang Haifang1,Liu Yongping2,Yin MingMing2,Su Lebin1,Xie Shimin1,Liu Lixin1,Yang Wen1ORCID,Chen Yi2,Dong Jianyu3ORCID,Zhou Yongbo1ORCID,Yin Shuang-Feng1ORCID

Affiliation:

1. Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

2. School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China

3. Department of Educational Science, Hunan First Normal University, Changsha 410205, China

Abstract

Selective condensation/bicycloaromatization of two different arylalkynes is firstly developed under ligand-free copper(i)-catalysis, which allows the direct synthesis of C–N axial biaryl compounds in high yields with excellent selectivity and functional group tolerance.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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5. Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis

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