In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics

Author:

Steinbrueck Axel1234ORCID,Sedgwick Adam C.1234,Han Hai-Hao56789,Zhao Michael Y.1234,Sen Sajal1234ORCID,Huang Dan-Ying1234,Zang Yi1011121314,Li Jia1011121314,He Xiao-Peng56789,Sessler Jonathan L.1234ORCID

Affiliation:

1. Department of Chemistry

2. University of Texas at Austin

3. Austin

4. USA

5. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering

6. Feringa Nobel Prize Scientist Joint Research Center

7. Frontiers Center for Materiobiology and Dynamic Chemistry

8. School of Chemistry and Molecular Engineering

9. East China University of Science and Technology

10. National Center for Drug Screening

11. State Key Laboratory of Drug Research

12. Shanghai Institute of Materia Medica

13. Chinese Academy of Sciences

14. Shanghai 201203

Abstract

We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells.

Funder

National Natural Science Foundation of China

Welch Foundation

National Cancer Institute

Science and Technology Commission of Shanghai Municipality

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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