Author:
Gaur Kavita,Vázquez-Salgado Alexandra,Duran-Camacho Geraldo,Dominguez-Martinez Irivette,Benjamín-Rivera Josué,Fernández-Vega Lauren,Carmona Sarabia Lesly,Cruz García Angelys,Pérez-Deliz Felipe,Méndez Román José,Vega-Cartagena Melissa,Loza-Rosas Sergio,Rodriguez Acevedo Xaymara,Tinoco Arthur
Abstract
A very promising direction in the development of anticancer drugs is inhibiting the molecular pathways that keep cancer cells alive and able to metastasize. Copper and iron are two essential metals that play significant roles in the rapid proliferation of cancer cells and several chelators have been studied to suppress the bioavailability of these metals in the cells. This review discusses the major contributions that Cu and Fe play in the progression and spreading of cancer and evaluates select Cu and Fe chelators that demonstrate great promise as anticancer drugs. Efforts to improve the cellular delivery, efficacy, and tumor responsiveness of these chelators are also presented including a transmetallation strategy for dual targeting of Cu and Fe. To elucidate the effectiveness and specificity of Cu and Fe chelators for treating cancer, analytical tools are described for measuring Cu and Fe levels and for tracking the metals in cells, tissue, and the body.
Funder
National Institute of General Medical Sciences
Cited by
62 articles.
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