Targeting the colchicine site in tubulin through cyclohexanedione derivatives-Reference-Cited by-同舟云学术

Targeting the colchicine site in tubulin through cyclohexanedione derivatives

Published:2016 Issue:23 Volume:6 Page:19492-19506
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Canela María-Dolores¹²³,Bueno Oskía¹²³,Noppen Sam⁴⁵⁶⁷,Sáez Calvo Gonzalo⁸⁹³,Estévez Gallego Juan⁸⁹³,Díaz J. F.⁸⁹³,Camarasa María-José¹²³,Liekens Sandra⁴⁵⁶⁷,Pérez-Pérez María-Jesús¹²³,Priego Eva-María¹²³^ORCID

Affiliation:

1. Instituto de Química Médica (IQM-CSIC)

2. E-28006 Madrid

3. Spain

4. KU Leuven – University of Leuven

5. Rega Institute for Medical Research

6. B-3000 Leuven

7. Belgium

8. Centro de Investigaciones Biológicas (CIB-CSIC)

9. E-28040 Madrid

Abstract

Cyclohexanedione derivatives, a new family of colchicine-site binders, have been further explored with the aid of docking studies, resulting in compounds with improved solubility and K_a value for tubulin.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA26807A

Reference29 articles.

1. The Tubulin Code

2. Drugs that target dynamic microtubules: A new molecular perspective

3. Vascular-disrupting agents in oncology

4. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

5. An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

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