Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles-Reference-Cited by-同舟云学术

Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles

Published:2017 Issue:6 Volume:2 Page:896-907
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Damião Mariana C. F. C. B.¹²³⁴,Galaverna Renan¹²³⁴,Kozikowski Alan P.⁵⁶⁷⁸,Eubanks James⁹¹⁰¹¹¹²,Pastre Julio C.¹²³⁴^ORCID

Affiliation:

1. Institute of Chemistry

2. University of Campinas - UNICAMP

3. Campinas

4. Brazil

5. StarWise Therapeutics LLC

6. University Research Park

7. Madison

8. USA

9. Division of Genetics and Development

10. Krembil Research Institute

11. Toronto

12. Canada

Abstract

An integrated continuous flow process for the synthesis of 3-thio-1,2,4-triazoles is reported. A small library of 18 compounds was prepared in just 48 minutes of residence time in moderate to excellent yields.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RE/C7RE00125H

Reference98 articles.

1. Medicinal Chemistry: Challenges and Opportunities

2. Continuous-flow organic synthesis: a tool for the modern medicinal chemist

3. Green process chemistry in the pharmaceutical industry

4. Cradle-to-gate life cycle inventory and assessment of pharmaceutical compounds

5. Fast life cycle assessment of synthetic chemistry (FLASC™) tool

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of the telescoped flow Pd-catalyzed aerobic alcohol oxidation/reductive amination sequence in the synthesis of new phosphatidylinositide 3-kinase inhibitor (CPL302415);RSC Advances;2024

2. Synthesis of novel antipyrine-azole-S-alkyl derivatives antimicrobial activity, molecular docking, and computational studies;Journal of Molecular Structure;2022-07

3. The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles;Multicomponent Reactions towards Heterocycles;2021-11-26

4. Synthesis, Docking and Antiepileptic Activity of New 2-((1,5-Diphenyl-1H-1,2,4-Triazol-3-yl)Thio)-N-Phenylacetamide Derivatives;Polycyclic Aromatic Compounds;2021-09-29

5. ASSESSMENT OF THE IMPACT OF CONTINOUS FLOW CHEMISTRY ON MODERN HETEROCYCLIC CHEMISTRY;2021