Continuous-time binding kinetics of graphene oxide quantum dots and lipid bilayers dominated by hydrogen bonding: effect of nanoparticles' protein corona and membrane components

Author:

Ren Chaoxiu1,Wang Kaili12,Ge Xinran1,Wu Tao2ORCID,Zhou Qixing3ORCID

Affiliation:

1. Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China

2. Beijing Key Laboratory of Enze Biomass Fine Chemicals, College of New Materials and Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, China

3. Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China

Abstract

Binding of graphene oxide quantum dots to model membranes is hampered by cholesterol, ganglioside GM1 and protein corona, which is dominated by hydrogen bonding. This study might have implications in studies of the nanotoxicity at atomic resolution.

Funder

Beijing Nova Program

Beijing Municipal Education Commission

Publisher

Royal Society of Chemistry (RSC)

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