Development of <i>Moringa oleifera</i> as functional food targeting NRF2 signaling: antioxidant and anti-inflammatory activity in experimental model systems-Reference-Cited by-同舟云学术

Development of Moringa oleifera as functional food targeting NRF2 signaling: antioxidant and anti-inflammatory activity in experimental model systems

Published:2023 Issue:10 Volume:14 Page:4734-4751
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Manjunath Souparnika H.¹,Nataraj Prabhakaran²,Swamy Vikas H.³,Sugur Kavya¹^ORCID,Dey Sumit K.¹,Ranganathan Veena¹,Daniel Shyni²,Leihang Zonunsiami¹,Sharon Veronica¹,Chandrashekharappa Sandeep⁴^ORCID,Sajeev Nithin⁵,Venkatareddy Venkataramana G.²,Chuturgoon Anil⁶^ORCID,Kuppusamy Gowthamarajan⁷,Madhunapantula SubbaRao V.¹,Thimmulappa Rajesh K.¹^ORCID

Affiliation:

1. Department of Biochemistry, Centre of Excellence in Molecular biology & Regenerative Medicine, Jagadguru Sri Shivarathreeshwara (JSS) Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore, Karnataka, 570015, India

2. Department of Studies in Environmental Sciences, University of Mysore, Mysore, Karnataka, 570005, India

3. Department of Biochemistry, School of Life Science, JSS AHER, Mysore, Karnataka, 570015, India

4. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER-R) Raebareli, Transit Campus, Lucknow, UP 226002, India

5. SCIEX, DHR Holding India Pvt Ltd, Bangalore 562149, India

6. Discipline of Medical Biochemistry, University of Kwa-Zulu Natal, Durban 4041, South Africa

7. Department of Pharmaceutics, JSS College of Pharmacy, JSS AHER, Ooty, Nilgiris, Tamil Nadu 643001, India

Abstract

Pharmacological activation of nuclear factor erythroid 2 related factor 2 (NRF2) by Moringa oleifera leaves protects against environmental diseases by inhibiting oxidative and inflammatory injury.

Funder

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00572K

Reference66 articles.

1. The Lancet Commission on pollution and health

2. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

3. Deficiency in Nrf2-GSH Signaling Impairs Type II Cell Growth and Enhances Sensitivity to Oxidants

4. Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

5. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

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