Okanin from <i>Coreopsis tinctoria</i> Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia-Reference-Cited by-同舟云学术

Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia

Published:2023 Issue:1 Volume:14 Page:369-387
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Mi Yan¹²,Xu Jikai¹²,Shi Ruijia¹,Meng Qingqi¹,Xu Libin¹,Liu Yeshu¹,Guo Tingting³,Zhou Di³,Liu Jingyu¹,Li Wei⁴^ORCID,Li Ning³,Hou Yue¹²^ORCID

Affiliation:

1. College of Life and Health Sciences, National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang, China

2. Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang, China

3. School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China

4. Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan

Abstract

Okanin attenuated cognitive impairment in BCCAO mice. Okanin inhibited microglial activation, decreased NLRP3 inflammasome activation and increased miR-7 expression in vivo and in vitro, and inhibited microglia-induced neuronal injury.

Funder

Fundamental Research Funds for the Central Universities

Higher Education Discipline Innovation Project

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources

National Natural Science Foundation of China

Liaoning Revitalization Talents Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO01476A