Vinyl sulfonamide synthesis for irreversible tethering via a novel α-selenoether protection strategy
Author:
Affiliation:
1. Department of Chemistry
2. Imperial College London
3. Molecular Sciences Research Hub
4. London W12 0BZ
5. UK
6. Department of Life Sciences
7. London SW7 2AZ
Abstract
A novel strategy for the synthesis of vinyl sulfonamide fragments for application to irreversible protein tethering.
Funder
Engineering and Physical Sciences Research Council
Biotechnology and Biological Sciences Research Council
Imperial College London
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00566D
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1. Proteome-wide covalent ligand discovery in native biological systems
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3. Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases
4. Covalent tethering of fragments for covalent probe discovery
5. High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery
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