Reactivity <i>vs.</i> selectivity of quinone methides: synthesis of pharmaceutically important molecules, toxicity and biological applications-Reference-Cited by-同舟云学术

Reactivity vs. selectivity of quinone methides: synthesis of pharmaceutically important molecules, toxicity and biological applications

Published:2022 Issue:42 Volume:58 Page:6160-6175
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ali Kasim¹²,Mishra Prajjval¹,Kumar Awnish¹,Reddy Damodara N¹²,Chowdhury Sushobhan¹,Panda Gautam¹²^ORCID

Affiliation:

1. Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Sector 10, Lucknow 226031, UP, India

2. Academy of Scientific & Industrial Research (AcSIR), Ghaziabad, Uttar Pradesh-201 002, India

Abstract

The synthetic routes, structure–reactivity relationships and synthetic applications of quinone methides, along with possible chemical manifestations leading to their toxicity in biological systems, are discussed.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00838F

Reference143 articles.

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2. Substituents on Quinone Methides Strongly Modulate Formation and Stability of Their Nucleophilic Adducts

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4. Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

5. Dynamic Cross-Linking Is Retained in Duplex DNA after Multiple Exchange of Strands

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