Nelumbo nucifera leaf polyphenol extract and gallic acid inhibit TNF-α-induced vascular smooth muscle cell proliferation and migration involving the regulation of miR-21, miR-143 and miR-145-Reference-Cited by-同舟云学术

Nelumbo nucifera leaf polyphenol extract and gallic acid inhibit TNF-α-induced vascular smooth muscle cell proliferation and migration involving the regulation of miR-21, miR-143 and miR-145

Published:2020 Issue:10 Volume:11 Page:8602-8611
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chung Dai-Jung¹²³⁴⁵,Wu Yi-Liang⁶⁷⁸⁵⁹,Yang Mon-Yuan¹²³⁴⁵,Chan Kuei-Chuan¹⁰¹¹⁵⁹¹⁰,Lee Huei-Jane¹²¹³⁴⁵⁹^ORCID,Wang Chau-Jong¹⁴⁸⁵⁹¹⁵^ORCID

Affiliation:

1. Institute of Biochemistry

2. Microbiology

3. and Immunology

4. Chung Shan Medical University

5. Taichung 40201

6. Division of Cardiovascular Surgery

7. Surgical Department

8. Chung Shan Medical University Hospital

9. Taiwan

10. Department of Internal Medicine

11. Chung-Shan Medical University Hospital

12. Department of Biochemistry

13. School of Medicine

14. Department of Medical Research

15. Department of Health Diet and Industry Management

Abstract

The NLPE and GA potentially prevent atherosclerosis by inhibiting VSMC migration and proliferation. The mechanisms involve the regulation of the miRNA in PTEN, Ras/extracellularsignal-regulated kinase pathway, and Rho family proteins.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/FO/D0FO02135K

Reference49 articles.

1. Myostatin Inhibits Vascular Smooth Muscle Cell Proliferation and Local 14q32 microRNA Expression, But Not Systemic Inflammation or Restenosis

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3. Progress and challenges in translating the biology of atherosclerosis