Determination of danofloxacin and its photodegradation products by HPLC-DAD. Kinetic evaluation of the degradation process and identification of photoproducts by mass spectrometry

Author:

Hubicka Urszula1234,Żuromska-Witek Barbara1234,Żmudzki Paweł5234,Stanisławski Michał1234,Krzek Jan1234

Affiliation:

1. Department of Inorganic and Analytical Chemistry

2. Jagiellonian University Medical College

3. Faculty of Pharmacy

4. 30-688 Kraków, Poland

5. Department of Medicinal Chemistry

Abstract

A HPLC method was developed for determination of danofloxacin (DAN) in the presence of its photodegradation products.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference25 articles.

1. Micelle enhanced and terbium sensitized spectrofluorimetric determination of danofloxacin in milk using molecularly imprinted solid phase extraction

2. Formulation and stability testing of photolabile drugs

3. New Planar Chromatography-Densitometry Methods for Determination of Drug Substances and Formulations

4. ICH-Q1B Stability Testing, Photostability Testing of New Drug Substances and Products, International Conference on Harmonization, Geneva, November 2005, http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q1B/Step4/Q1B_Guideline.pdf

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