Efficient turn-on Zr based metal organic framework fluorescent sensor for ultrafast detection of danofloxacin in milk samples

Abstract

Abstract Metal organic framework, UiO-67 was synthesized by coordinating Zr(IV) with 4,4'-biphenyldicarboxylic acid (BPDC) ligand. Morphology and crystallinity of MOF was confirmed with FE-SEM and PXRD procedure. Danofloxacin (DANO), a veterinary antibiotic, was detected in milk by employing UiO-67 as “turn-on” fluorescent sensor. Original photoluminescent (PL) efficiency of UiO-67 sensor was enhanced on its electronic interaction with DANO molecule. Significant PL efficiency enhancement, lower detection limit 0.49 ng/mL (1.37 nM), swift detection (< 1 min), and excellent linear correlation (R2 = 0.9988) indicated extraordinary sensitivity of developed MOF sensor for DANO. Selectivity and performance of sensor was unaltered in presence of interfering species and detection results were obtained under permissible variation limits. Method applied successfully for ultra-trace detection of DANO residues in milk samples.