Discovery of a photoactivatable dimerized STING agonist based on the benzo[<i>b</i>]selenophene scaffold-Reference-Cited by-同舟云学术

Discovery of a photoactivatable dimerized STING agonist based on the benzo[b]selenophene scaffold

Published:2023 Issue:15 Volume:14 Page:4174-4182
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Dongyu¹,Yu Bin¹,Guan Xin²,Song Bin¹,Pan Huikai¹,Wang Renbing¹,Feng Xi¹,Pan Lixia²,Huang Huidan³,Wang Zhe¹^ORCID,Wu Hongxi¹,Qiu Zhixia¹,Li Zhiyu¹,Bian Jinlei¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211100, P. R. China

2. State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning, 530007, P. R. China

3. Department of Pharmaceutical Engineering, School of Pharmacy, Wannan Medical College, Wuhu, China

Abstract

The first photoactivatable STING agonist, caged-diBSP01, is presented based on a novel and potent dimerized STING agonist diBSP01. Caged-diBSP01 allowed spatiotemporal control of STING activation by light, which was well characterized both in vitro and in vivo.

Funder

National Natural Science Foundation of China

Outstanding Youth Foundation of Jiangsu Province of China

Qinglan Project of Jiangsu Province of China

National College Students Innovation and Entrepreneurship Training Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC06860E

Reference38 articles.