Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth

Author:

Ding Chunyong12ORCID,Du Mengyan345,Xiong Zhi16,Wang Xue1,Li Hongji1,He Ende1,Li Han35,Dang Yijing7ORCID,Lu Qing1,Li Shicong1,Xiao Ruoxuan1,Xu Zhiai7ORCID,Jing Lili1,Deng Liufu1,Wang Xiyuan3ORCID,Geng Meiyu34,Xie Zuoquan34,Zhang Ao1

Affiliation:

1. Shanghai Frontiers Science Center of Drug Target Identification and Delivery, College of Pharmaceutical Sciences, National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China

2. Zhangjiang Institute of Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China

3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China

4. University of Chinese Academy of Sciences, Beijing, 100049, China

5. School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China

6. School of Pharmacy, Nanchang University, Jiangxi 330000, China

7. School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China

Abstract

A photo-caged STING agonist featuring a tumor-targeting carbonic anhydrase warhead was designed and synthesized for photo-controllable activation of STING signaling.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Shanghai Jiao Tong University

Shanghai Municipal Health and Family Planning Commission

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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