Exploitation of new structurally diverse d-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential-Reference-Cited by-同舟云学术

Exploitation of new structurally diverse d-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential

Published:2017 Issue:21 Volume:15 Page:4667-4680
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xavier Nuno M.¹²³⁴⁵^ORCID,Porcheron Alexandre¹²³⁴⁵,Batista Daniela¹²³⁴⁵^ORCID,Jorda Radek⁶⁷⁸⁹¹⁰^ORCID,Řezníčková Eva⁶⁷⁸⁹¹⁰^ORCID,Kryštof Vladimír⁶⁷⁸⁹¹⁰^ORCID,Oliveira M. Conceição¹¹¹²³¹³⁵^ORCID

Affiliation:

1. Centro de Química e Bioquímica

2. Faculdade de Ciências

3. Universidade de Lisboa

4. 1749-016 Lisboa

5. Portugal

6. Laboratory of Growth Regulators

7. Centre of the Region Haná for Biotechnological and Agricultural Research

8. Palacký University & Institute of Experimental Botany AS CR

9. 78371 Olomouc

10. Czech Republic

11. Centro de Química Estrutural (CQE)

12. Instituto Superior Técnico

13. 1049-001 Lisboa

Abstract

The synthesis of novel d-glucuronamide-based N-glycosyl derivatives is described. An N-dodecyl-containing N⁹-glycosylpurine displayed anticancer effects with single-digit micromolar GI₅₀ values.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00472A

Reference68 articles.

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