Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents-Reference-Cited by-同舟云学术

Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents

Published:2019 Issue:5 Volume:17 Page:1062-1066
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chen Huiqing¹²³⁴⁵,Xie Jia⁶⁷³⁴⁵,Xing Dong¹²³⁴⁵^ORCID,Wang Jinping¹²³⁴⁵,Tang Jie¹²³⁴⁵,Yi Zhengfang⁶⁷³⁴⁵,Xia Fei¹²³⁴⁵^ORCID,Qiu Wen-Wei¹²³⁴⁵,Yang Fan¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development

2. School of Chemistry and Molecular Engineering

3. East China Normal University

4. Shanghai

5. China

6. Shanghai key Laboratory of Regulatory Biology

7. Institute of Biomedical Sciences and School of Life Sciences

Abstract

We report an efficient and highly diastereoselective protocol for the rapid construction of 3-nitro substituted 4-chromanones by an intramolecular Michael-type cyclization of α-nitro aryl ketones bearing unsaturated ester units.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02761G

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