Discovery, Synthesis, and Pharmacological Evaluation of Spiropiperidine Hydroxamic Acid Based Derivatives as Structurally Novel Histone Deacetylase (HDAC) Inhibitors-Reference-Cited by-同舟云学术

Discovery, Synthesis, and Pharmacological Evaluation of Spiropiperidine Hydroxamic Acid Based Derivatives as Structurally Novel Histone Deacetylase (HDAC) Inhibitors

Published:2011-04-01 Issue:8 Volume:54 Page:3051-3064
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Varasi Mario¹²,Thaler Florian²³,Abate Agnese¹²,Bigogno Chiara⁴,Boggio Roberto³,Carenzi Giacomo¹²,Cataudella Tiziana¹,Dal Zuffo Roberto³,Fulco Maria Carmela¹²,Rozio Marco Giulio⁴,Mai Antonello⁵,Dondio Giulio⁴,Minucci Saverio²⁶,Mercurio Ciro¹

Affiliation:

1. Genextra Group, DAC SRL, Via Adamello 16, 20139 Milan, Italy

2. European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy

3. Genextra Group, Congenia SRL, Via Adamello 16, 20139 Milan, Italy

4. NiKem Research SRL, Via Zambeletti 25, 20021 Baranzate (MI), Italy

5. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy

6. Department of Biomolecular Sciences and Biotechnologies, University of Milan, Via Celoria, 26, 20133 Milan, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200146u

Reference46 articles.

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3. Histone deacetylases (HDACs): characterization of the classical HDAC family

4. The many roles of histone deacetylases in development and physiology: implications for disease and therapy

5. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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