Identification of macrocyclic peptides which activate bacterial cylindrical proteases-Reference-Cited by-同舟云学术

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Identification of macrocyclic peptides which activate bacterial cylindrical proteases

Published:2023 Issue:6 Volume:14 Page:1186-1191
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Walther Raoul¹^ORCID,Westermann Linda M.²,Carmali Sheiliza³^ORCID,Jackson Sophie E.¹,Brötz-Oesterhelt Heike²⁴^ORCID,Spring David R.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK

2. Interfaculty Institute of Microbiology and Infection Medicine, Dept. of Bioactive Compounds, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany

3. School of Pharmacy, Queen's University Belfast, BT9 7BL Belfast, UK

4. Cluster of Excellence Controlling Microbes to Fight Infections, Germany

Abstract

This work reports a divergent peptide stapling strategy to identify macrocyclic peptides which increase the proteolytic activity of the proteolytic core of the caseinolytic protease.

Funder

Danmarks Frie Forskningsfond

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Medical Research Council

UK Research and Innovation

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00136A

Reference37 articles.

1. Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules

2. Conformational control of the bacterial Clp protease by natural product antibiotics

3. Bacterial proteases, untapped antimicrobial drug targets

4. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

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