Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators-Reference-Cited by-同舟云学术

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators

Published:2023 Issue:7 Volume:14 Page:1272-1295
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Zhang Xujie¹^ORCID,Sun Lin¹²,Xu Shujing¹,Huang Tianguang¹,Zhao Fabao¹,Ding Dang¹,Liu Chuanfeng¹,Jiang Xiangyi¹^ORCID,Tao Yucen¹^ORCID,Kang Dongwei¹^ORCID,De Clercq Erik³^ORCID,Pannecouque Christophe³^ORCID,Cocklin Simon⁴,Dick Alexej⁵,Liu Xinyong¹^ORCID,Zhan Peng¹

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China

2. Department of Pharmacy, Qilu Hospital of Shandong University, 107 West Culture Road, Jinan 250012, Shandong, PR China

3. Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), 3000, Leuven, Belgium

4. Specifica, Inc., 1607 Alcaldesa Street, Santa Fe, NM, 87501, USA

5. Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, PA 19102, USA

Abstract

We report the design, synthesis, and mechanistic study of a novel series of 2-piperazineone peptidomimetics as HIV capsid modulators by mimicking the structure of host factors binding to CA.

Funder

National Natural Science Foundation of China

Shandong University

Taishan Scholar Project of Shandong Province

Natural Science Foundation of Shandong Province

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00134B