Application of primary halogenated hydrocarbons for the synthesis of 3-aryl and 3-alkyl indolizines

Author:

Liu Yan12345,Hu Huayou12345ORCID,Zhou Junyu6784,Wang Wenhui569104,He Youliang569104,Wang Chao1234

Affiliation:

1. School of Material Science and Engineering

2. Southwest University of Science and Technology

3. Mianyang 621010

4. P. R. China

5. Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials

6. School of Chemistry and Chemical Engineering

7. Nanjing University

8. Nanjing 210023

9. Huaiyin Normal University

10. Huaian 223300

Abstract

A transition-metal-free synthetic route to 3-aryl and 3-alkyl indolizines from electron-deficient alkenes, pyridines and primary halogenated hydrocarbons is reported for the first time using a tandem reaction.

Funder

Basic Research Program of Jiangsu Education Department

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Huaiyin Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference73 articles.

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2. W. Flisch , in Comprehensive Heterocyclic Chemistry, ed. A. R. Katritzky and C. W. Rees, Pergamon, Oxford, 1984, vol. 4, p. 476

3. An Alkaloid Related to Dehydrolaudanosoline

4. Synthesis Pathways to Erythrina Alkaloids and Erythrina Type Compounds

5. Indolizidine and quinolizidine alkaloids

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