Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation

Author:

Pan Hong-Yu12ORCID,Ye Zhi-Wei12,Zheng Qian-Wang12,Yun Fan3,Tu Ming-Zhen1,Hong Wei-Guo1,Chen Bai-Xiong12,Guo Li-Qiong12,Lin Jun-Fang12

Affiliation:

1. College of Food Science & Institute of Food Biotechnology, South China Agricultural University, Guangzhou 510640, China

2. Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou 510640, China

3. Guangzhou Alchemy Biotechnology Co., Guangzhou 510760, China

Abstract

Postulated mechanisms of lifespan extension by EGT: preservation of CNS via the coordination of cholinergic neurotransmission, tyrosine metabolism, and peroxisomal proteins, regulated autophagic activity, and preservation of mitochondrial function.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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