Modeling the archetype cysteine protease reaction using dispersion corrected density functional methods in ONIOM-type hybrid QM/MM calculations; the proteolytic reaction of papain-Reference-Cited by-同舟云学术

Modeling the archetype cysteine protease reaction using dispersion corrected density functional methods in ONIOM-type hybrid QM/MM calculations; the proteolytic reaction of papain

Published:2016 Issue:48 Volume:18 Page:32847-32861
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Fekete Attila¹²³⁴⁵^ORCID,Komáromi István¹²³⁴⁵

Affiliation:

1. Division of Clinical Laboratory Science

2. Department of Laboratory Medicine

3. Faculty of Medicine

4. University of Debrecen

5. Debrecen

Abstract

A proteolytic reaction of papain with a simple peptide model substrateN-methylacetamide has been studied.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C6CP06869C

Reference81 articles.

1. Structure of Papain

2. The structure and mechanism of action of papain

3. L. Polgar , in Handbook of Proteolytic Enzymes, ed. A. J. Barrett, N. D. Rawlings and W. J. Fred, Academic Press, 3rd edn, 2013, ch. 405, vol. 2, pp. 1773–1784

4. Current problems in mechanistic studies of serine and cysteine proteinases

5. The mechanism of action of thiolenzymes

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