Papain-Mediated Conjugation of Peptide Nucleic Acids to Delivery Peptides: A Density Functional Theory/Molecular Mechanics Metadynamics Study in Aqueous and Organic Solvent-Reference-Cited by-同舟云学术

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Papain-Mediated Conjugation of Peptide Nucleic Acids to Delivery Peptides: A Density Functional Theory/Molecular Mechanics Metadynamics Study in Aqueous and Organic Solvent

Published:2024-07-25 Issue:31 Volume:128 Page:7500-7512
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

González Ricardo D.¹²³^ORCID,Carvalho Alexandra T. P.¹²⁴

Affiliation:

1. CNC-UC − Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal

2. CIBB − Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra 3004-504, Portugal

3. Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra 3030-789, Portugal

4. Almac Sciences, Department of Biocatalysis and Isotope Chemistry, Almac House, 20 Seagoe Industrial Estate ,Craigavon, Northern Ireland BT63 5QD, United Kingdom

Funder

European Regional Development Fund

Funda??o para a Ci?ncia e a Tecnologia

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.4c02294

Reference64 articles.

1. Sequence-selective DNA recognition by synthetic ligands

2. The peptide nucleic acids (PNAs), powerful tools for molecular genetics and cytogenetics

3. Advances in oligonucleotide drug delivery

4. A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides

5. Peptide nucleic acid (PNA) cell penetrating peptide (CPP) conjugates as carriers for cellular delivery of antisense oligomers

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