Enantio- and diastereodivergent synthesis of fused indolizines enabled by synergistic Cu/Ir catalysis-Reference-Cited by-同舟云学术

Enantio- and diastereodivergent synthesis of fused indolizines enabled by synergistic Cu/Ir catalysis

Published:2023 Issue:15 Volume:14 Page:4134-4142
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhu Bing-Ke¹²,Xu Hui³,Xiao Lu¹,Chang Xin¹,Wei Liang¹^ORCID,Teng Huailong⁴^ORCID,Dang Yanfeng³^ORCID,Dong Xiu-Qin¹^ORCID,Wang Chun-Jiang¹²^ORCID

Affiliation:

1. College of Chemistry and Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, Wuhan University, Wuhan, Hubei, 430072, P. R. China

2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 230021, China

3. Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, Tianjin University, Tianjin 300072, China

4. College of Science, Huazhong Agricultural University, Wuhan, 430070, P. R. China

Abstract

Highly selective assembly of 2,3-fused indolizines was achievedviaa cascade allylation/Friedel–Crafts type reaction with Cu/Ir catalysis. This protocol furnishes a stereodivergent synthesis of chiral indolizines bearing three stereogenic centers with excellent results.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00118K

Reference103 articles.

1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. Indolizine: a biologically active moiety