Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives-Reference-Cited by-同舟云学术

Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

Published:2018 Issue:7 Volume:16 Page:1079-1082
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Huang Jian Qiang¹²³⁴⁵,Nairoukh Zackaria¹²³⁴⁵,Marek Ilan¹²³⁴⁵^ORCID

Affiliation:

1. The Mallat Family Laboratory of Organic Chemistry

2. Schulich Faculty of Chemistry

3. Technion-Israel Institute of Technology

4. Haifa, 32000

5. Israel

Abstract

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

Funder

FP7 Ideas: European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00067K

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